Human Factor Alpha XIIa Purified from Innovative Research has been prepared from Human Factor XII using Dextran Sulfate, and then purified to remove the activator. This is a frozen liquid buffered in 4 mM sodium acetate-HCl/ 0.15 M NaCl/ pH 5.3, with a concentration of 1mg/ml. Complete activation was observed by SDS-PAGE analysis.
Factor alpha-XIIa activates Factor XI to FXIa as part of the contact activation pathway in the coagulation cascade. Factor XIIa activates prekallikrein to kallikrein, which in turn converts FXII to FXIIa in a reciprocal activation mechanism that triggers the contact factor cascade.
More Details:
- Source: Human Plasma
- Purification: Prepared from Human Factor XII using Dextran Sulfate (which was then removed by purification)
- Purity: Complete activation observed on SDS-PAGE
- Storage Conditions: -60 to -80C
At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.
Please note – this product replaces our old product number IHFXIIa (same product, new number).